Table 3.
Outcome prediction at birth: uni- and multivariate association of clinical and demographic parameters known at birth with mortality, adverse outcome and unfavourable outcome
|
MORTALITY |
Univariate model† |
|
Multivariate model‡ |
|
|---|---|---|---|---|
| OR(95%-CI) | p-value | OR(95%-CI) | p-value | |
|
Gestational age (weeks) |
0.39 (0.34 - 0.44) |
<0.001 |
0.40 (0.35 - 0.47) |
<0.001 |
|
BW z-score |
0.64 (0.56 - 0.74) |
<0.001 |
NA |
|
|
BW z-score < −2 |
6.99 (3.09 - 15.85) |
<0.001 |
11.68 (4.73 - 28.86) |
<0.001 |
|
BW z-score −2 to −1 |
2.10 (1.46 - 3.03) |
<0.001 |
2.71 (11.78 - 4.12) |
<0.001 |
|
Male sex |
1.06 (0.82 - 1.35) |
0.67 |
1.15 (0.86 - 1.54) |
0.33 |
|
Outborn |
0.80 (0.45 - 1.45) |
0.47 |
NA |
|
|
Antenatal corticosteroids |
0.34 (0.26 - 0.44) |
<0.001 |
0.46 (0.34 - 0.62) |
<0.001 |
|
Caesarean delivery |
0.49 (0.37 - 0.65) |
<0.001 |
NA |
|
|
Multiple pregnancy |
1.02 (0.77 - 1.34) |
0.90 |
1.27 (0.91 - 1.78) |
0.16 |
|
ADVERSE OUTCOME |
Univariate model† |
|
Multivariate model‡ |
|
| |
OR(95%-CI) |
p-value |
OR(95%-CI) |
p-value |
|
Gestational age (weeks) |
0.47 (0.41 - 0.53) |
<0.001 |
0.49 (0.42 - 0.56) |
<0.001 |
|
BW z-score |
0.71 (0.62 - 0.88) |
<0.001 |
NA |
|
|
BW z-score < −2 |
5.36 (2.22 - 12.90) |
<0.001 |
7.90 (3.08 - 20.25) |
<0.001 |
|
BW z-score −2 to −1 |
1.91 (1.32 - 2.78) |
<0.001 |
2.35 (1.59 - 3.55) |
<0.001 |
|
Male sex |
1.20 (0.94 - 1.54) |
0.15 |
1.34 (1.01 - 1.77) |
0.042 |
|
Outborn |
0.98 (0.53 - 1.81) |
0.95 |
NA |
|
|
Antenatal corticosteroids |
0.40 (0.31 - 0.53) |
<0.001 |
0.51 (0.38 - 0.69) |
<0.001 |
|
Caesarean delivery |
0.53 (0.39 - 0.70) |
<0.001 |
NA |
|
|
Multiple pregnancy |
0.96 (0.73 - 1.27) |
0.80 |
1.19 (0.87 - 1.64) |
0.28 |
|
UNFAVOURABLE OUTCOME |
Univariate model† |
|
Multivariate model‡ |
|
| |
OR(95%-CI) |
p-value |
OR(95%-CI) |
p-value |
|
Gestational age (weeks) |
0.52 (0.45 - 0.59) |
<0.001 |
0.54 (0.47 - 0.61) |
<0.001 |
|
BW z-score |
0.73 (0.63 - 0.85) |
<0.001 |
NA |
|
|
BW z-score < −2 |
12.05 (2.82 - 51.48) |
<0.001 |
16.91 (3.84 - 74.47) |
<0.001 |
|
BW z-score −2 to −1 |
1.59 (1.08 - 2.33) |
0.019 |
1.82 (1.20 - 2.74) |
0.004 |
|
Male sex |
1.24 (0.96 - 1.59) |
0.09 |
1.35 (1.02 - 1.77) |
0.033 |
|
Outborn |
1.30 (0.68 - 2.49) |
0.42 |
NA |
|
|
Antenatal corticosteroids |
0.48 (0.36 - 0.63) |
<0.001 |
0.57 (0.43 - 0.77) |
<0.001 |
|
Caesarean delivery |
0.69 (0.51 - 0.93) |
<0.001 |
NA |
|
| Multiple pregnancy | 1.05 (0.79 - 1.38) | 0.76 | 1.31 (0.96 - 1.78) | 0.087 |
The table gives all parameters that showed an unequal distribution among groups as shown in Table I or that are known from previous publications to act as confounders. † The univariate model is adjusted for study centre and year group. ‡ The multivariate model contains all parameters that were associated with the outcome in the univariate model.
CI, confidence interval; OR, Odd’s ratio; BW, birth weight.