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Inhibition of CVB3 by over-expressing MAVS, coinciding with IFNs increase. After transfection with pcDNA3.1 and pcDNA3.1-FLAG-MAVS, HeLa cells were infected with CVB3-woodruff. At 0 h, 6 h, 12 h, 24 h and 36 h post-infection, cells were harvested, and RT-qPCR was performed to determine the change of (A) CVB3 replication, (B) IFN-β mRNA and (C) IFN-α mRNA. * p < 0.05,** p < 0.01.
