Table 3.
Diagnostic performance of BNP0 and ΔBNP on clinical outcomes
| Outcomes | AU-ROC | Cutoff (pg/ml) | Sensitivity | Specificity | LR+ | LR− |
|---|---|---|---|---|---|---|
| BNP0 | ||||||
| Mortality |
0.71 (0.59-0.84) |
>816 |
48.2 |
87.5 |
3.85 |
0.59 |
| Duration of MV > 7 days |
0.79 (0.62-0.85) |
>929 |
57.1 |
88.2 |
4.86 |
0.49 |
| LOS in ICU > 7 days |
0.66 (0.53-0.79) |
>828 |
40 |
89.2 |
3.70 |
0.67 |
| LOS in hospital > 12 days |
0.71 (0.58-0.83) |
>709 |
60.6 |
70.6 |
2.06 |
0.56 |
| ΔBNP | ||||||
| Mortality |
0.58 (0.44-0.72) |
>294 |
40.7 |
77.5 |
1.81 |
0.76 |
| Duration of MV > 7 days |
0.80 (0.60-0.99) |
>108 |
52.9 |
85.7 |
3.71 |
0.55 |
| LOS in ICU > 7 days |
0.84 (0.74-0.93) |
>101 |
73.0 |
80.0 |
3.65 |
0.34 |
| LOS in hospital > 12 days | 0.85 (0.75-0.94) | >114 | 73.5 | 87.9 | 6.07 | 0.30 |
BNP0 represents the B-type natriuretic peptide measured on ICU entry; ΔBNP represents the difference between BNP measured on the third day and BNP0 (BNP1-BNP0);
Abbreviation: LOS, length of stay; MV, mechanical ventilation.