Figure 4.

MAPC treatment reduces BBB permeability after TBI. BBB permeability measurement was completed using Evan’s blue dye as mean absorbance (nm) normalized to tissue weight (grams) derived from homogenized cortical tissue derived from the hemisphere ipsilateral to the CCI injury. Mice showed an increase in BBB permeability after CCI alone that was reversed by the intravenous injection of MAPC. * represents P <0.05 and *** represents P <0.005. BBB, blood brain barrier; MAPC, multipotent adult progenitor cell; TBI, traumatic brain injury.