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. 2013 Jan 16;8(1):e54398. doi: 10.1371/journal.pone.0054398

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© 2013 Vrba et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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miRNA genes are listed on the left, sample names are on the top. miRNA promoters that have significant ≥20% increase in DNA methylation within the whole MassARRAY amplicon relative to normal samples are in black. For a select set of miRNAs, 14 additional breast cancer specimens were analyzed. Cancer cell lines and tumor tissue samples are separated by vertical grey line. The mir-31 promoter of MB231 sample is grey because this cell line has a homozygous deletion of this region.