Table 1. Unmodified and PS-modified SL2-B aptamer sequences along with their equilibrium dissociation constant (Kd) values determined using surface plasmon resonance (SPR) spectroscopy.
Sequences of original and PS-modified aptamer (5′–3′) | Kd |
Unmodified SL2-B aptamer CAATTGGGCCCGTCCGTATGGTGGGT | 0.50±0.32 nM |
PS-modified SL2-B aptamer C*AATTGGGCCCGTCCGTATGGTGGG*T | 0.56±0.44 nM |
“*” indicates the position of phosphorothioate (PS) modification.