Table 1. Characteristics of the breast cancer studies.

	Sequencing	RPBCMS	MARIE cases
n	50	296	2,715
Age at diagnosis (years)	58.3±13.4	59.7±13.3	62.4±6.1
Percentage of premenopausal women	31.3%	34.3%	9.2%
Histology
IDC	74.0%	75.0%	66.3%
ILC	16.0%	15.5%	19.9%
DCIS		1.7%	6.3%
other	10.0%	7.8%	7.3%
Tumour size
with the diameter lessthan 2 cm	54.0%	58.0%	51.5%
with the diameter morethan 2 cm	46.0%	42.0%	42.2%
Tumour grade
I	4.0%	8.0%	17.4%
II	78.0%	69.5%	48.1%
III	18.0%	22.5%	28.1%
Oestrogen receptor status
positive	84.0%	86.3%	79.0%
negative	16.0%	13.7%	21.0%
Progesterone receptor status
positive	76.0%	75.2%	67.0%
negative	24.0%	24.8%	33.0%

Notes: the age at diagnosis is indicated as mean value ± standard deviation.

Abbreviations:

IDC… infiltrative ductal carcinoma.

ILC… infiltrative lobular carcinoma.

DCIS… ductal carcinoma in situ.

RPBCMS… Risk Prediction of Breast Cancer Metastasis Study.