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. Author manuscript; available in PMC: 2013 Jan 16.
Published in final edited form as: Angiogenesis. 2008 Sep 17;11(4):347–360. doi: 10.1007/s10456-008-9116-2

Fig. 3.

Fig. 3

A PCP-deficient point-mutation form of Dvl2 (K446M-Dvl2) disrupts endothelial cell proliferation. a Western blot of Dvl2 constructs in MPE whole cell lysates. b Expression of WT or DIX-deleted forms of Dvl2 did not affect MPE cell proliferation. MPE cells that expressed either ΔPDZ or ΔDEP mutants were not viable and were therefore not included in this assay. However, endothelial cells expressing K446M-Dvl2 were predominantly cytostatic (***; P <0.001, N = 4/group, triplicate experiments)