Figure 4.

Intrapleural fibrinolytic therapy of pleural fibrosis in rabbits with overexpression of hPAI-1 and TCN-induced injury. Animals transduced with AdPAI-1/AdlacZ overexpressed hPAI-1 in the pleural space, and developed pleural effusions and adhesions 2 days after TCN was administered intrapleurally (see Figure 3C). When these animals were treated with single-chain uPA (scuPA) (0.5 mg per kg) (B) or tissue-type plasminogen activator (tPA) (0.145 mg per kg) (C), most of the pleural adhesions were effectively cleared 24 hours later. In contrast, control animals treated with PBS (A) demonstrated a severe, complex organization and adhesion formation.