Figure 1.

Adoptive transfer of T regulatory cells (Tregs; CD4⁺CD25⁺ cells) but not CD4⁺CD25⁻ cells into Rag-1^−/− mice restored normal resolution of lung injury. (A) Survival curves after intratracheal LPS for all groups (*P = 0.021 by survival log-rank, and ^#P = 0.024 by χ² test, n ≥ 14 in all groups). (B) Weight loss presented as percentage of baseline weight after intratracheal LPS for all groups (*P < 0.001, and ^#P < 0.001, n ≥ 14, all groups). (C) Bronchoalveolar lavage (BAL) cell counts on Day 3 and Day 7 after intratracheal LPS or intratracheal water for all groups (*P = 0.012 and ^#P < 0.05, n > 4, all groups). (D) BAL protein measured by the method of Lowry on Day 3 and Day 7 after intratracheal LPS or intratracheal water for all groups (*P = 0.001 and ^#P = 0.006, n ≥ 4 all groups). AT, adoptive transfer; WT, wild-type.