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. 2013 Jan;48(1):53–62. doi: 10.1165/rcmb.2011-0344OC

Figure 1.

Figure 1.

Effect of rosiglitazone (RGZ) on perinatal nicotine exposure–induced alterations in total resistance and compliance of the lung after methacholine (Mch) challenge in male and female rats. Compared with the control group, with nicotine administration there was a significant increase in resistance and a decrease in compliance of the lung after an Mch challenge, which were both blocked by concomitant RGZ administration in both the males (A and D) and females (B and E). Please note that, compared with the female group, with nicotine administration there was a significant increase in resistance (C), and a significant decrease in compliance (F) of the lung after an Mch challenge in the male rats. Values are means (±SE) (n = 5–6 for each group). *P < 0.05, **P < 0.01 versus control; #P < 0.05, ##P < 0.01 versus nicotine group; ‡P < 0.05, ‡‡P < 0.01 versus female group.