Figure 5.
Effects of ozone inhalation on resistance spectra curves (RL) and elastance spectra curves (EL) in Sftpd+/+ and Sftpd−/− mice. Lung function was measured 72 hours after exposure of Sftpd+/+ and Sftpd−/− mice to air or ozone. Lungs were subjected to increasing PEEP. Impedance spectra were generated using the forced oscillation technique. Resistance and elastance spectra were then derived from input impedance data. Measurements were performed in triplicate at each PEEP. Each point represents the mean ± SEM of three experiments (n = 4–6 mice/treatment group/experiment; n = 12–27 mice/group total). Data were analyzed by nonlinear regression. *Significantly different (P ≤ 0.05) from air-exposed control mice.