. Author manuscript; available in PMC: 2014 Feb 1.

Published in final edited form as: Psychopharmacology (Berl). 2012 Sep 14;225(3):707–718. doi: 10.1007/s00213-012-2860-4

Table 3.

Serum levels of COC and its metabolites

Serum levels of COC and its metabolites in male and female C57BL/6 mice 15 minutes after an injection of 30 mg/kg COC. Mice in the single dose paradigm received just one injection of 30 mg/kg COC while mice in the ascending binge paradigms received three sequential COC doses (5, 15, and 30 mg/kg). n=8 per group, total n=32. Mean ng/mL serum ± SEM.

	Single Dose		Ascending Binge Doses
Analyte	Males	Females	Males	Females
COC	1111 ± 159	773 ± 102	1018 ± 149	945 ± 144
NC	241 ± 27	234 ± 11	208 ± 31	249 ± 31
EME	2053 ± 174	1923 ± 71	2056 ± 161	1908 ± 134
BE	2349 ± 120	3285 ± 176 ^*	3010 ± 94 ^~	3776 ± 204 ^*^~

Indicates effect of sex (females greater than males),

indicates effect of treatment (ascending binge greater than single dose).