Table 4. Expression Levels of Genes Belonging to GR Functionality (FKBP-4, FKBP-5, and GR), Inflammation (IL-1α, IL-1β, IL-4, IL-6, IL-7, IL-8, IL-10, TNF-α, and MIF), and Neuroplasticity (BDNF, p11, and VGF) in Depressed Patients before (Patients T0) and after 8 Weeks of Antidepressant Treatment (Patients T8).

Gene	Patients T0	Patients T8	Time effect		Time × response interaction		Time × drug interaction
			F value	p-Value	F value	p-Value	F value	p-Value
FKBP-4	0.99±0.01	0.98±0.01	0.9	0.4	0.04	0.9	0.4	0.6
FKBP-5	1.26±0.02	1.17±0.02	8.5	0.005	4.4	0.04	0.05	0.8
GR	0.85±0.01	0.89±0.01	7.3	0.009	0.2	0.7	1.1	0.3
IL-1α	1.00±0.02	1.02±0.02	1.6	0.2	2.2	0.1	0.9	0.4
IL-1β	1.51±0.03	1.45±0.03	7.9	0.006	1.7	0.20	1.7	0.2
IL-4	0.90±0.02	0.96±0.03	3.4	0.07	0.02	0.9	0.1	0.7
IL-6	1.32±0.01	1.26±0.02	4.7	0.03	10.02	0.002	4.4	0.04
IL-7	0.99±0.02	1.00±0.03	0.3	0.6	1.8	0.2	<0.01	0.9
IL-8	1.01±0.01	1.02±0.01	0.06	0.8	0.9	0.4	0.1	0.7
IL-10	1.02±0.01	1.02±0.02	0.09	0.8	0.5	0.5	<0.01	1.0
MIF	1.30±0.03	1.06±0.06	16.4	<0.0001	0.06	0.8	1.1	0.3
TNF-α	1.55±0.04	1.52±0.04	0.3	0.6	0.03	0.9	0.2	0.7
BDNF	0.71±0.01	1.10±0.03	120.5	<0.0001	17.8	<0.0001	3.6	0.06
P11	0.85±0.03	0.93±0.02	8.4	0.005	0.3	0.6	0.05	0.8
VGF	0.65±0.04	0.79±0.04	4.8	0.033	4.4	0.04	0.03	0.9

Statistics (F and p values) are presented for the time effect as well as the time × response and time × drug interactions. The numbers of patients for each group were: 26 responders to escitalopram, 12 non-responders to escitalopram, 25 responders to nortryptline, and 11 non responders to nortryptline).