Figure 5.

Ceftriaxone rescues downregulation of excitatory amino-acid transporter 2 (EAAT2) and astrocytic aquaporin 4 (AQP4) in equilibrative nucleoside transporter 1 (ENT1) null mice. (a, b) In the caudate-putamen (CPu), both (a) mRNA and (b) protein levels of EAAT2 and AQP4 were upregulated after ceftriaxone treatment (200 mg/kg, intraperitoneal) in ENT1 null and wild-type mice (n=4∼7). (c) However, in the nucleus accumbens (NAc), EAAT2, and AQP4 mRNA levels were upregulated, (d) whereas only EAAT2 protein levels were increased after the treatment (n=4∼7). GAPDH was used as a control. sal=saline; cef=ceftriaxone. *p<0.05 compared with the saline treatment groups (Tukey post-hoc test), and ^#p<0.05 for the main effect of treatment. All data are expressed as mean±SEM.