Table 2. MANCOVA Model: Metabolites/Cre Ratio as Dependent Variables and Age, Gender, Group, and Bcl-2 Genotype as Covariates.

Dependent variable	Covariate	B	SE	t	Sig.	Partial eta squared (%)	Observed power (%)
Glu/Cre
	Age	0.006	0.005	1314	0.193	2.3	25.4
	Gender	0.013	0.056	0.233	0.816	0.1	5.6
	Group	0.484	0.148	3261	0.002	12.9	89.6
	Bcl-2 genotype (AG)	0.001	0.127	0.007	0.995	0.0	5.0
	Bcl-2 genotype (GG)	0.024	0.127	0.192	0.848	0.1	5.4
	Bcl-2 genotype (AA)	0a	–	–	–	–	–
	Group*Bcl-2 genotype (AG)	−0.359	0.167	−2154	0.035	6.1	56.6
	Group*Bcl-2 genotype (GG)	−0.468	0.171	−2745	0.008	9.5	77.3
	Group*Bcl-2 genotype (AA)	0a	–	–	–	–	–
Glx/Cre
	Age	0.009	0.006	1496	0.139	3.0	31.5
	Gender	−0.002	0.071	−0.034	0.973	0.0	5.0
	Group	0.667	0.187	3557	0.001	14.9	93.9
	Bcl-2 genotype (AG)	0.002	0.161	0.011	0.991	0.0	5.0
	Bcl-2 genotype (GG)	0.014	0.161	0.085	0.933	0.0	5.1
	Bcl-2 genotype (AA)	0a	–	–	–	–	–
	Group*Bcl-2 genotype (AG)	−0.488	0.211	−2.32	0.023	7.0	62.9
	Group*Bcl-2 genotype (GG)	−0.621	0.215	−2887	0.005	10.4	81.3
	Group*Bcl-2 genotype (AA)	0a	–	–	–	–	–

Abbreviations: Cre, creatine phosphocreatine; Glu, glutamate; Glx, glutamate+glutamine.

^aThis parameter is set to zero because it is redundant.

Significance level p<0.05.