Table 2c. Functional Outcome Measuresa.
| Test | Study Arm | N |
Week 0 |
Week 12 |
Week 36 |
Significant |
|---|---|---|---|---|---|---|
| Mean (SD) | Mean (SD) | Mean (SD) | ||||
| Social Skills Assessment (score) | 𝒟-Serine+CRT | 24 | −0.14 (1.31) | −0.05 (1.06) | −0.09 (1.04) | CRT × time (p=0.07) |
| 𝒟-Serine+Placebo CRT | 27 | 0.17 (0.77) | 0.00 (1.14) | −0.06 (1.18) | ||
| CRT+Placebo 𝒟-Serine | 27 | 0.03 (0.95) | 0.26 (0.78) | 0.24 (0.82) | ||
| Placebo 𝒟-Serine+Placebo CRT | 26 | −0.08 (0.94) | −0.22 (0.97) | −0.11 (0.92) | ||
| Medication Management Ability Assessment (score) | 𝒟-Serine+CRT | 24 | 0.04 (1.08) | 0.06 (1.00) | 0.00 (1.14) | 𝒟-serine × site × time (p=0.02) |
| 𝒟-Serine+Placebo CRT | 27 | 0.05 (1.05) | 0.07 (1.13) | 0.24 (0.77) | ||
| CRT+Placebo 𝒟-Serine | 27 | 0.02 (0.82) | −0.08 (0.98) | −0.08 (1.13) | ||
| Placebo 𝒟-Serine+Placebo CRT | 26 | −0.11 (1.07) | −0.04 (0.90) | −0.17 (0.92) | ||
| UCSD Performance- Based Skills Assessment (score) | 𝒟-Serine+CRT | 24 | 0.04 (0.96) | 0.05 (1.25) | 0.15 (1.24) | |
| 𝒟-Serine+Placebo CRT | 27 | 0.16 (1.06) | 0.02 (0.89) | 0.01 (0.92) | ||
| CRT+Placebo 𝒟-Serine | 27 | −0.23 (0.87) | −0.01 (0.88) | −0.04 (0.87) | ||
| Placebo 𝒟-Serine+Placebo CRT | 26 | 0.04 (1.08) | −0.06 (0.99) | −0.11 (0.98) | ||
| Heinrichs-Carpenter Quality of Life (score) | 𝒟-Serine+CRT | 24 | −0.24 (1.06) | −0.11 (1.07) | −0.09 (1.04) | |
| 𝒟-Serine+Placebo CRT | 27 | 0.12 (0.89) | 0.04 (0.89) | −0.05 (0.85) | ||
| CRT+Placebo 𝒟-Serine | 27 | 0.11 (1.04) | 0.11 (1.16) | 0.07 (1.07) | ||
| Placebo 𝒟-Serine+Placebo CRT | 26 | −0.02 (1.02) | −0.05 (0.87) | 0.06 (1.06) |
Abbreviation: CRT, cognitive retraining.
a
Values are reported as z-scores because of between-site heterogeneity.