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. 2012 Nov 7;38(3):513–524. doi: 10.1038/npp.2012.213

Figure 4.

Figure 4

Clozapine (CLZ) tolerance induced in adolescence and assessed in adulthood. Number of avoidance responses (a) and intertrial crossing (b) made by the rats from the CS-only, CLZ (10.0 mg/kg), CLZ (20.0 mg/kg), and vehicle (VEH) groups on the last training (predrug) day and throughout the five drug test days are expressed as mean+SEM. The same three measures on the seventh retraining day and the first CLZ tolerance test day (approximate postnatal days (∼P) 76) are also expressed as mean+SEM and depicted in c and d, respectively. Data from the predrug day and the second CLZ tolerance test day (∼P 92) are depicted in e (avoidance) and f (intertrial crossing), respectively. *p<0.05 relative to the VEH group; #p<0.05 relative to the CS-only group.