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. 2012 Dec 28;10(2):110–118. doi: 10.7150/ijms.5123

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Representative DCE-MR images of locally advanced breast cancers before and after NACT. Signal of the tumor and the swelling left axillary lymph node involved were markedly enhanced after contrast agent injected (A-B). 3D-MIP of contrast-enhanced T1-weighted images highlighted the irregular boundary of the tumor with marked enhancement and neovascularization around the tumor (C). The steep time-signal intensity curve suggested that contrast agents wash-in and wash-out the tumor quickly (D, E). After chemotherapy, the tumor and the swelling left axillary lymph node involved shrank (F, G), and the neovascularity reduced mildly (H). There was a platform appeared in the time-signal intensity curve when the signal of the tumor reached a peak (I, J).