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. 2012 Dec 28;10(2):110–118. doi: 10.7150/ijms.5123

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Representative DCE-MR images of locally advanced breast cancers before and after NACT+rh-endostatin treatment. The tumor was difficult to be differentiated from the normal gland tissue (A, F). The swelling left axillary lymph node involved shrank significantly after NACT+rh-endostatin (B, G). 3D-MIP of contrast-enhaced T1-weighted images showed the obvious reduction of the tumor volume and angiogenesis. (C, H). The slope of time-signal intensity curve of the tumor decreased significantly (D, E, I, J).