Table 3.
Genotypes of the PCSK9 E670G SNP and serum lipid levels between non-drinkers and drinkers and the interactions between genotypes and alcohol consumption on serum lipid parameters.
| Group | Genotype | n | TC (mmol/L) |
TG (mmol/L) |
HDL-C (mmol/L) |
LDL-C (mmol/L) |
ApoA1 (g/L) |
ApoB (g/L) |
ApoA1/ApoB |
|---|---|---|---|---|---|---|---|---|---|
| Non-drinker | AA | 744 | 4.84±1.07 | 1.02(0.73) | 1.74±0.44 | 2.94±0.81 | 1.35±0.29 | 0.92±0.22 | 1.55±0.49 |
| AG | 41 | 4.55±0.64 | 1.10(0.58) | 1.63±0.50 | 2.69±0.44 | 1.28±0.31 | 0.89±0.21 | 1.55±0.56 | |
| F | - | - | 3.849 | 0.081 | 2.523 | 4.547 | 2.521 | 1.090 | 0.008 |
| P | - | - | 0.050 | 0.935 | 0.113 | 0.033 | 0.113 | 0.297 | 0.928 |
| Drinker | AA | 543 | 4.59±0.99↓ | 1.23(0.92) | 1.82±0.49 | 2.55±0.82↓ | 1.48±0.32 | 0.85±0.25 | 1.96±1.10 |
| AG | 24 | 5.01±1.25 | 1.09(0.78) | 1.86±0.51 | 2.68±0.86 | 1.44±0.28 | 0.89±0.32 | 2.06±1.56 | |
| F | - | - | 4.415 | 0.212 | 0.110 | 0.692 | 0.353 | 0.634 | 0.240 |
| P | - | - | 0.036 | 0.832 | 0.741 | 0.406 | 0.553 | 0.426 | 0.625 |
| F1 | - | - | 4.518 | 2.839 | 1.908 | 4.644 | 0.249 | 0.256 | 1.002 |
| P1 | - | - | 0.032 | 0.092 | 0.167 | 0.029 | 0.618 | 0.613 | 0.317 |
TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B. All data are expressed as mean ± SD [the values of TG are presented as median (interquartile range)]. The values of F1 and P1 of the drinkers are the interactions between the PCSK9 E670G genotypes and alcohol consumption on serum lipid parameters. ↓, genotype and alcohol consumption interactions to decrease serum lipid levels.