Table 3. Allelic associations for ERAP1 and HLA-C genes in psoriasis patients stratified for age at onset (case versus controls).
|
Age at onset |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Age 0–9 |
Age 10–20 |
Age 21–40 |
Age >40 |
|||||||||
| Marker | MAF ca | P1 | OR (95% CI) | MAF ca | P1 | OR (95% CI) | MAF ca | P1 | OR (95% CI) | MAF ca | P1 | OR (95% CI) |
| rs26653 | 0.30 | 0.4 | 1.24 (0.93–1.65) | 0.36 | 0.00008 | 1.59 (1.28–1.98) | 0.31 | 0.05 | 1.27 (1.05–1.54) | 0.30 | 0.1 | 1.21 (1.01–1.44) |
| rs30187 | 0.39 | 0.4 | 1.20 (0.91–1.57) | 0.43 | 0.0001 | 1.46 (1.18–1.80) | 0.35 | 1 | 1.03 (0.85–1.24) | 0.37 | 0.5 | 1.11 (0.93–1.31) |
| rs27524 | 0.39 | 0.4 | 1.12 (0.86–1.47) | 0.42 | 0.02 | 1.28 (1.04–1.58) | 0.36 | 1 | 0.98 (0.81–1.18) | 0.38 | 0.5 | 1.09 (0.92–1.29) |
| rs10484554 | 0.33 | 2.5 × 10−28 | 4.66 (3.48–6.24) | 0.42 | 2.9 × 10−72 | 6.65 (5.29–8.35) | 0.31 | 4.6 × 10−46 | 4.25 (3.44–5.24) | 0.15 | 0.0005 | 1.59 (1.25–2.02) |
| HLA-Cw06:02 | 0.29 | 1.2 × 10−33 | 5.71 (4.19–7.79) | 0.38 | 1.3 × 10−86 | 8.46 (6.65–10.77) | 0.28 | 8.9 × 10−58 | 5.52 (4.40–6.92) | 0.12 | 9.1 × 10−6 | 1.89 (1.45–2.46) |
Abbreviations: CI, confidence interval; ERAP, endoplasmic reticulum aminopeptidase 1; MAF ca, minor allele frequency cases; OR, odds ratio.
1
Adjusted P-value for five tests with Holm as implemented in PLINK adjust.