Figure 1.

Pedigree of the index patient and family members carrying the DPYD c.1905+1G>A mutation. The index patient is indicated by an arrow. For family members who were alive, age at the time of the study is shown below in italics. For deceased members, designated by a diagonal line through the symbol, age and cause of death are annotated (CRC, colorectal cancer; AMI, acute myocardial infarction). Numbers inside a diamond are children of unspecified sex. DPYD genotypes are wild type (−/−), heterozygous (+/−) and homozygous (+/+) carriers of the mutation.