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Effects of selective nNOS inhibition with SMTC on HR and MAP in healthy and CHF rats
| Healthy | CHF | |||||
|---|---|---|---|---|---|---|
| Control | SMTC | Δ | Control | SMTC | Δ | |
| Rest | ||||||
| HR (bpm) | 351 ± 9 | 319 ± 8* | −32 ± 8 | 371 ± 8 | 353 ± 8*† | −18 ± 9 |
| MAP (mmHg) | 111 ± 4 | 131 ± 5* | 19 ± 3 | 124 ± 4† | 134 ± 5* | 11 ± 3† |
| Contractions (steady-state) | ||||||
| HR (bpm) | 352 ± 9 | 323 ± 9* | −30 ± 7 | 372 ± 9 | 354 ± 7*† | −18 ± 9 |
| MAP (mmHg) | 115 ± 4 | 133 ± 5* | 18 ± 2 | 124 ± 4 | 132 ± 6* | 10 ± 2† |
Values are means ± SEM, *P < 0.05 versus control, †P < 0.05 versus healthy.
