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. 2013 Jan 17;3:1081. doi: 10.1038/srep01081

Figure 2. Disturbing the excitation-inhibition balance alters the developmental trajectory.

Figure 2

(a–c), The application of Bicuculline (50 μM), APV (100 μM) and Octanol (0.25 mM) breaks the excitation-inhibition balance and alters the trajectory. In the PC space, the inherent developmental sequence is shown by the grayscale trajectory (black to white) and the recovering track left by firing patterns after washing out drugs is indicated by colorized dots (light yellow to dark red). The green dots indicate the original firing patterns before the drug was applied. The black arrow and the red arrow indicates the direction of sequential state transitions during development, and the direction of changing firing patterns after the drug was washed out, respectively. Note firing patterns return to the approximately original position through the unidirectional recovering process, leaving a track pointed to the position where firing patterns before drug was applied (green dots). (Total recorded life span of the cultured network: 147 DIV, Experiment Day: APV: 33 DIV; BIC: 51 DIV, OCT: 101 DIV). Data are available online. DIV: days in vitro.