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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Dec 10;23(3):682–686. doi: 10.1016/j.bmcl.2012.11.111

Table 1.

Inhibitory activities of compounds 1 and 2a–c

Compound IC50 (nM)a
Kinase 1 2a 2b 2c
Abl <2.54 2953 749.8 135.8
Kit 14.70 32.50 9.96 54.94
DDR2 <2.54 653.3 178.6 17.22
FLT3 9548 973.9 117.8 882.0
LCK 108.2 44620 11050 1448
LYN 1281 45420 15150 3534
PDGFRα <2.54 83.87 25.96 8.20
PDGFRβ 60.11 35400 >5000 768.4
a

Assay details are provided by Reaction Biology Corp. via the internet at www.reactionbiology.com