FIGURE 2.

Proliferative effects of PKC isozymes in T cells. Positive and negative proliferative effects of individual PKC isozymes are indicated by green arrows and red barred lines, respectively. Proposed cell cycle targets in the growth-inhibitory and growth-stimulatory effects of PKCθ are shown. These targets reflect the importance of D-type cyclins and Cip/Kip ckis as targets for PKC signaling, as seen in other systems (note that in pre-T cells, cyclin D1 appears to be the target for PKCθ). The dashed lines indicate the lack of knowledge of specific cell cycle targets for other PKC isozymes in T cells.