Table 5.
Association between selected characteristics and p53 overexpression
| Characteristics | p53 overexpression, no. (%) | No p53 overexpression, no. | Unadjusted OR (95% CI) | Adjusted OR (95% CI)* | P |
|---|---|---|---|---|---|
| Age (y) | |||||
| ≤60 | 21 (8.2) | 234 | 1.00 | 1.00 | 0.06 |
| 61–67 | 20 (9.0) | 202 | 1.10 (0.58–2.09) | 1.01 (0.49–2.10) | |
| 68–72 | 12 (5.7) | 197 | 0.68 (0.33–1.41) | 0.50 (0.21–1.16) | |
| >72 | 10 (4.7) | 204 | 0.55 (0.25–1.19) | 0.51 (0.21–1.27) | |
| Gender | |||||
| Female | 18 (6.2) | 273 | 1.00 | 1.00 | 0.46 |
| Male | 45 (7.4) | 564 | 1.21 (0.69–2.13) | 1.28 (0.67–2.46) | |
| Family history† | |||||
| No | 58 (7.8) | 690 | 1.00 | 1.00 | 0.10 |
| Yes | 5 (3.3) | 147 | 0.40 (0.16–1.03) | 0.40 (0.14–1.19) | |
| Previous polyp‡ | |||||
| No | 50 (9.7) | 468 | 1.00 | 1.00 | 0.03 |
| Yes | 7 (2.3) | 296 | 0.22 (0.10–0.49) | 0.35 (0.14–0.88) | |
| No. of adenomas at baseline | |||||
| 1 | 36 (7.1) | 471 | 1.00 | 1.00 | 0.84 |
| 2 | 14 (6.8) | 193 | 0.95 (0.50–1.80) | 1.16 (0.56–2.42) | |
| >2 | 13 (7.0) | 173 | 0.98 (0.51–1.90) | 1.05 (0.44–2.50) | |
| Adenoma location | |||||
| Distal colon | 41 (9.2) | 403 | 1.00 | 1.00 | 0.85 |
| Proximal colon | 10 (3.4) | 280 | 0.35 (0.17–0.71) | 0.71 (0.29–1.78) | |
| Rectum | 6 (7.4) | 75 | 0.79 (0.32–1.92) | 0.85 (0.33–2.19) | |
| Size (cm) | |||||
| <1 | 10 (1.8) | 535 | 1.00 | 1.00 | <0.0001 |
| ≥1 | 51 (14.4) | 302 | 9.03 (4.52–18.06) | 5.25 (2.39–11.5) | |
| Dysplasia | |||||
| Low grade | 31 (4.5) | 650 | 1.00 | 1.00 | 0.05 |
| High grade | 32 (15.7) | 172 | 3.90 (2.32–6.57) | 1.88 (1.01–3.51) | |
| Histology | |||||
| Tubular | 24 (3.7) | 631 | 1.00 | 1.00 | 0.04 |
| Tubulovillous or villous | 39 (16.1) | 203 | 5.05 (2.97–8.60) | 1.96 (1.03–3.71) | |
| Advanced adenoma§ | |||||
| No | 7 (1.6) | 423 | 1.00 | 1.00 | <0.0001 |
| Yes | 56 (10.6) | 414 | 8.17 (3.68–18.14) | 7.20 (3.01–17.22) |
*
Advanced adenoma ORs were adjusted for previous polyps and location. All other factors were adjusted for previous polyp, location, size, dysplasia, and histology.
†
History of colorectal cancer in one or more first-degree relatives.
‡
Self-reported history of a polyp prior to baseline adenoma.
§
Includes one or more of the following characteristics: tubulovillous or villous histology, ≥1 cm in size, or HGD.