Table 6.
Association between selected characteristics and Ki-ras mutation and/or p53 overexpression
| Characteristics | Ki-ras and p53-negative (n = 701) | Ki-ras or p53-positive (n = 154) | Ki-ras and p53-positive (n = 17) | P * |
|---|---|---|---|---|
| Age, y (SE) | 66.1 (0.33) | 66.5 (0.60) | 67.8 (1.22) | 0.04 |
| Male (%) | 67.3 | 68.4 | 69.5 | 0.75 |
| Family history (%)† | 18.1 | 13.4 | 9.8 | 0.11 |
| Previous polyp (%)‡ | 40.0 | 22.3 | 11.0 | <0.0001 |
| No. of adenomas (SE) | 1.81 (0.05) | 1.89 (0.08) | 1.96 (0.17) | 0.40 |
| Rectal adenomas (%) | 9.1 | 13.8 | 20.2 | 0.04 |
| Size, mm (SE) | 7.8 (0.23) | 12.0 (0.41) | 16.2 (0.84) | <0.0001 |
| HGD (%) | 18.6 | 41.0 | 67.9 | <0.0001 |
| Tubulovillous/villous histology (%) | 19.3 | 54.6 | 85.8 | <0.0001 |
| Advanced adenomas (%)§ | 44.9 | 79.5 | 94.8 | <0.0001 |
*
χ2 for categorical variables and P trends for continuous variables (adjusted for age and number of adenomas).
†
History of colorectal cancer in one or more first-degree relatives.
‡
Self-reported history of polyps prior to baseline adenoma.
§
Includes one or more of the following characteristics: tubulovillous or villous histology, ≥1 cm in size, or HGD.