Table 1.
Comparison of siRNA with Current Treatments
| siRNA | Chemo/radiation | Vaccine | |
|---|---|---|---|
| Target | All HPV Genes | All cells | L1, L2 |
| Prophylactic | ✓ | ✘ | ✓ |
| Therapeutic | ✓ | ✓ | ✘ |
| Long-lasting | ✘ | ✘ | ✓ |
| Specificity | High | Low | High |
| HPV types | All | All | 2-4 |
| Warts | ✓ | ✘ | ✓ |
| CIN/AIN/VIN | ✓ | ✓ | ✓ |
| Laryngeal Papillomatosis | ✓ | ✓ | ✓ |
SiRNA therapies show major advantages over other forms of treatment including specificity, broad application and reduced toxicity. CIN, cervical intraepithelial neoplasia; AIN, anal intraepithelial neoplasia; VIN, vulval intraepithelial neoplasia.