Table 1. Comparison of Electrophysiological Properties of Serotonin Neuronsa.
| 5-HT1A-positive
serotonin neurons (n = 112) |
5-HT1A-negative
serotonin neurons (n = 22) |
||||
|---|---|---|---|---|---|
| parameter | mean | SEM | mean | SEM | t test comparison (P values) |
| membrane potential (mV) | –58.79 | 0.41 | –60.73 | 1.1 | 0.1707 |
| input resistance (mohm) | 1023.10 | 40.58 | 910.96 | 61.04 | 0.1291 |
| time constant (ms) | 83.06 | 3.86 | 78.35 | 6.61 | 0.5408 |
| capacitance (pF) | 84.17 | 3.40 | 84.43 | 4.39 | 0.9629 |
| rheobase (pA) | 31.15 | 2.44 | 37.33 | 7.83 | 0.4560 |
| action potential threshold (mV) | –39.88 | 0.38 | –40.08 | 0.83 | 0.8304 |
| action potential amplitude (mV) | 75.67 | 0.85 | 74.03 | 2.14 | 0.4802 |
| action potential duration (ms) | 1.55 | 0.04 | 1.77 | 0.12 | 0.0922 |
| afterhyperpolarization potential amplitude (mV) | –17.77 | 0.33 | –16.71 | 0.77 | 0.2111 |
| Afterhyperpolarization potential time to peak (ms) | 25.93 | 1.03 | 30.76 | 2.94 | 0.1304 |
a
Electrophysiological parameters were measured as described (see Methods). P values reported after Student’s t test with Welch’s correction.