Table 1. Cells Involved in Mediating Innate and Adaptive Immunitya.
| cell | immune function | serotonergic phenotype |
|---|---|---|
| innate immunity | ||
| macrophage | phagocytosis; APCs; secrete cytokines, GCSF, MCSF, interferons, TNFα and β, TGFβ | SERT; 5-HT receptors 5-HT1A, 5-HT2, 5-HT2A, 5-HT3, 5-HT4, 5-HT7 |
| mast cell | release heparin, histamine and serotonin; produce leukotrienes, prostaglandins, and PAF | SERT; 5-HT receptors 5-HT1A |
| dendritic cell | express MHC II (APCs) | SERT; 5-HT receptors 5-HT1B, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT3, 5-HT4, 5-HT7 |
| basophil | release heparin, histamine and serotonin | SERT? |
| neutrophil | phagocytosis | SERT?; 5-HT receptors 5-HT7 |
| eosinophil | phagocytosis; release histaminase and other enzymes involved in allergic and parasitic immune responses | SERT?; 5-HT receptors 5-HT2A |
| natural killer | express MHC I; Apoptosis of “non-self” cells | SERT?; 5-HT receptors 5-HT1A |
| adaptive immunity | ||
| T cells | activation of macrophages; cytotoxicity; memory | 5-HT receptors 5-HT1A, 5-HT1B, 5-HT2, 5-HT3, 5-HT7 |
| B cells | memory; antibody production | SERT; 5-HT receptors 5-HT1A, 5-HT2, 5-HT3, 5-HT7 |
a
Key: antigen-presenting cells (APCs); granulocyte colony stimulating factor (GCSF); monocyte colony stimulating factor (MCSF); tumor necrosis factor (TNF); transforming growth factor (TGF); platelet activating factor (PAF); major histocompatibility complex (MHC).