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. Author manuscript; available in PMC: 2013 Jul 15.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Jun 6;22(14):4579–4584. doi: 10.1016/j.bmcl.2012.05.107

Table 1.

SAR of 3-(3-(cyclopropanecarboxamido)-1H-indazol-6-yl-benzamides (I)

graphic file with name nihms417760t1.jpg
Cellular antiproliferative activity (EC50, µM)a
Compds Structure MOLM13
(FLT3)		 PDGFRα-
T674M-Ba/F3 		Kit-T607I-
Ba/F3 		wt-Ba/F3
4 graphic file with name nihms417760t2.jpg 0.005 0.017 0.198 >10
5 graphic file with name nihms417760t3.jpg 0.325 1.315 0.637 3.3
6 graphic file with name nihms417760t4.jpg 1.713 0.232 1.519 3.6
7 graphic file with name nihms417760t5.jpg >10 >10 >10 >10
8 graphic file with name nihms417760t6.jpg >10 >10 >10 >10
9 graphic file with name nihms417760t7.jpg 3.752 0.256 >10 2.0
a

Cellular antiproliferative activity (EC50, µM) on MOLM13, mutant PDGFRα–T674M–Ba/F3, mutant Kit–T670I–Ba/F3 and wt-Ba/F3, values are means of two experiments.