Table 1.
Effects of rosuvastatin and atorvastatin treatment on oxidative stress and liver fibrosis in thioacethamide-treated rats
| ALT | MDA nmole/g liver | Hydroxyproline (mg/g protein) | Fibrosis score (0-4) | Spleen weight (mg) | |
| Rosuvastatin dose (mg/kg) | |||||
| Control | 59 (44, 69) | 30.6 (20.5, 31.1) | 2.67 (1.9, 3.3) | 0 | 1200 (1100, 1400) |
| Ros 2.5 | 52 (47, 58) | 24.1 (19.8, 33.9) | 2.7 (2.2, 3.5) | 0 | 1020 (950, 1150) |
| Ros 5 | 50 (41, 57) | 31.3 (26.9, 36.7) | 2.8 (2.3, 3.1) | 0 | 1100 (950, 1300) |
| R 10 | 56 (46, 64) | 33.7 (27.7, 37.8) | 2.3 (1.8, 3.7) | 0 | 1000 (800, 1200) |
| R 20 | 44 (41, 47) | 29.4 (23.9, 39.6) | 3.9 (2.4, 4.2) | 0 | 1200 (900, 1200) |
| TAA | 63 (37, 79) | 48.7 (38.4, 50.2) | 11.2 (4.5, 15.4) | 4 (1.5, 4) | 1900 (1600, 2200) |
| TAA + R 2.5 | 53 (47, 63) | 22 (19, 31.2) | 7.5 (3.7, 13.1) | 2.5 (1, 4) | 1450 (1050, 1950) |
| TAA + R 5 | 54 (48, 67) | 36.5 (24.8, 52.1) | 11.0 (4.7, 16.2) | 3.25 (1, 4) | 1230 (1000, 1350) |
| TAA + R 10 | 51 (43, 60) | 37.8 (27.5, 44.9) | 11.8 (8.3, 16.2) | 3 (2, 4) | 1200 (1100, 1500) |
| TAA + R 20 | 51.5 (48, 55) | 39.2 (29.6, 46.8) | 12.3 (3.1, 14.3) | 3.5 (1, 4) | 1050 (900, 1300) |
| Atorvastatin dose (mg/kg) | |||||
| Control | 59 (44, 69) | 30.6 (20.5, 31.1) | 2.67 (1.9, 3.3) | 0 | 1200 (1100, 1400) |
| Ato 1 | 61 (55, 81) | 32.8 (27.4, 33.6) | 2.5 (2.1, 3.1) | 0 | 1300 (1100, 1400) |
| Ato 10 | 56 (53, 59) | 32.9 (29.1, 35.2) | 3.4 (1.6, 3.7) | 0 | 1200 (1100, 1300) |
| Ato 20 | 58 (48, 73) | 30.1 (29.8, 35.3) | 2.3 (1.95, 3) | 0 | 1100 (1100, 1200) |
| TAA | 63 (37, 79) | 48.7 (38.4, 50.2) | 11.2 (4.5, 15.4) | 4 (1.5, 4) | 1900 (1600, 2200) |
| TAA + Ato 1 | 49 (22, 70) | 46.6 (35.8, 63.1) | 9.1 (6.7, 16.1) | 3 (2, 4) | 1600 (900, 3000) |
| TAA + Ato 10 | 53 (47, 62) | 43.4 (36.2, 53.1) | 12.5 (6.9, 15.4) | 4 (2, 4) | 1500 (1400, 1700) |
| TAA + Ato 20 | 57 (43, 67) | 48.2 (34.2, 58.5) | 10.9 (5.3, 16.8) | 4 (3, 4) | 1500 (1300, 1700) |
n = 7, in the groups that received thioacethamide (TAA), n = 4 in the control, rosuvastatin only treated groups and atorvastatin only treated groups. TAA, 200 mg/kg ip twice weekly for 12 wk. Rosuvastatin and atorvastatin had given daily by nasogastric gavage. Ros: Rosuvastatin; ALT:Alanine transaminase; MDA: Malondialdehyde.