Figure 2.

Therapeutic effect of dEpoB, paclitaxel (Taxol), doxorubicin (Adriamycin), and vinblastine in nude mice bearing human chronic myelocytic leukemia tumor K562 xenograft. K562 tumor cells (1 × 10⁷, in 0.2 ml/mouse) were implanted s.c. on day 0. Every other day, treatments were given starting on day 20 with 30 mg/kg of dEpoB, 6-h i.v. infusion (□, n = 5); 20 mg/kg of Taxol 6-h i.v. infusion (Δ, n = 3); 3 mg/kg of Adriamycin, i.v. injection, (X, n = 4), and 2.5 mg/kg of vinblastine, i.v. injection (*, n = 4). The control mice (O, n = 4) received vehicle, Cremophor–ethanol (1:1), only. The vertical bars indicate mean tumor size in mm³ ± SE.