Figure 4.

Therapeutic effect of sequential treatment of mice bearing K562 xenografts with aza-dEpoB. K562 tumor tissue (1 × 10⁷ in 50 ml/mouse) was inoculated s.c. into nude mice on day 0. Mice were treated with 15 mg/kg of aza-dEpoB (Δ, n = 3), 6-h i.v. infusion on days 20, 22, 24, 26, 28, and 30. The same groups of mice were then treated with 30 mg/kg of dEpoF, 6-h i.v. infusion on days 42, 44, 46, 48, 52, and 54. On day 76, all three mice were tumor free. The control mice (O, n = 3) received vehicle (Cremophore–ethanol = 1:1) only.