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Structure and molecular ion of MMP-1, MMP-2/-9 substrate and products
| MMP-1 | MMP-2/-9 | |||
|---|---|---|---|---|
| Sequence | m/z of [M+H]+ | Sequence | m/z of [M+H]+ | |
| Substrate | DNP-Pro-Leu-Ala~Leu-Trp-Ala-Arg | 992.5 | DNP-Pro-Leu-Gly~Met-Trp-Ser-Arg | 1012.5 |
| N-terminal product (NTP) | DNP-Pro-Leu-Ala | 466.2 | DNP-Pro-Leu-Gly | 452.2 |
| C-terminal product (CTP) | Leu-Trp-Ala-Arg | 545.3 | Met-Trp-Ser-Arg | 579.3 |
DNP denotes - the 2,4-dinitrophenyl derivative to the terminal amine.
“~” denotes the enzyme cleavage site.
