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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Int Immunopharmacol. 2012 Aug 2;14(3):283–288. doi: 10.1016/j.intimp.2012.07.015

Figure 2. The role of FPR1 in human GBM.

Figure 2

FPR1 on GBM is activated by tumor and host cell-derived agonists, including Anx A1 released by necrotic tumor cells. Agonist binding to FPR1 in GBM cells activates regulatory molecules p38, MAPK, ERK1/2 and JUNK, and transcription factors NF-κB, STAT3 and HIF-1 to enhance cell chemotaxis, invasion, proliferation and production of angiogenic factors. FPR1 function in GBM cells is partially mediated by EGFR through a Src kinase-dependent transactivation pathway. The two receptors cooperate to promote the malignant behavior of GBM cells.