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. Author manuscript; available in PMC: 2013 Jan 17.
Published in final edited form as: Biomaterials. 2010 Mar 11;31(16):4530–4539. doi: 10.1016/j.biomaterials.2010.02.016

Table 2.

Delivery (EE%) of vitamin B12, antipyrine and 2-deoxlyglucose, and collected glucose concentration (mM) from PC probes.

VB12 (EE %) Antipyrine (EE %) 2-DG (EE %) Glucose (mM)
Probe DPP CP DPP CP DPP CP DPP CP
Day 0 26±3 29±4 56±7 59±6 53±12 53±11 4.8±0.6 4.4±0.8
Day 3 21±2 19±3 * 61±7 57±5 54±7 51±8 3.6±0.8 3.8±0.7
Day 4 17±7 62±5 53±6 3.1±1.0 *
Day 5 17±7 59±3 52±13 2.9±1.0 *
Day 6 13±10 ** 58±7 52±11 2.0±1.3**
Day 7 11±6 **† 9±5 **† 58±4 54±3 49±7 49±8 1.3±0.5**† 1.5±1.2**†

Two PC microdialysis probes were implanted per rat into the dorsal subcutaneous space, n=6 rats. The control probe (CP) was perfused with 100 µM VB12, 100 µM antipyrine and 5 mM 2-DG on day 0, day 3 and day 7 at 1 µL/min. Samples were collected every 30 min for 3 hrs (n=6). The daily-perfused probe (DPP) was perfused with the same solutions on day 0 and day 3 through day 7. Data represent mean ± SD, n=6 (average of 6 samples from 6 rats).

*

Significant differences from Day 0 at the p< 0.05

**

and p < 0.01 were determined using the repeated measurements of ANOVA.

†

denotes p <0.001 as compared to Day 0 (acute day) using non-parametric repeated ANOVA.