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Examples of various click reactions that are commonly used in bioconjugation or hydrogel cross-linking: (a) copper-catalyzed Huisgen cycloaddition, (b) strain-promoted azide–alkyne cycloaddition (SPAAC), (c) base-catalyzed thiol-vinyl sulfone, (d) base-catalyzed thiol-maleimide Michael addition, (e) photoinitiated thiol–ene photocoupling.
