Table 2.
Molar heat capacities of the solvate formation ΔCp= (Cp(solvate)- Cp(drug)- Cp(solvent))
| Heat capacity at 25°C (J/g/K) | Molar heat capacity at 25°C (J/(mol.K) | Molar heat capacity of solvent (J/(mol.K) at 25°C | ΔCpat 25°C (J/(mol.K) | |
|---|---|---|---|---|
|
Atorvastatin (anhydrous) (ATC) |
1.25±0.014 |
1514.43±0.11 |
- |
- |
|
Solvate- I (ATC + 0.5 Isopropyl alcohol) |
1.96±0.024 |
2347.86±0.05 |
77.0 |
756.42 |
|
Solvate- II (ATC + THF) |
2.07±0.003 |
2547.11±0.04 |
123.0 |
909.68 |
|
Solvate- III (ATC + Ethanol) |
1.98±0.007 |
2383.56±0.02 |
112.4 |
756.72 |
|
Solvate- IV (ATC + 0.5 t-butanol) |
2.44±0.004 |
2913.66±0.12 |
56.2 |
1343.02 |
|
Solvate- V (ATC + methanol) |
2.23±0.019 |
2720.96±0.12 |
159.0 |
1047.52 |
|
Solvate-VI (ATC + 1 Acetone +0.5 Ethanol) |
2.43±0.007 |
3009.49±0.05 |
181.7 |
1313.35 |
|
Solvate-VII (ATC + 0.5 Ethanol + Water) |
1.83±0.011 |
2234.91±0.06 |
131.4 |
589.10 |
| Solvate- VIII (ATC + 1- butanol) | 2.30±0.008 | 2840.19±0.02 | 174.3 | 1151.49 |