Table 5.
Breast cancer specific survival by Kaplan Meier analysis according to histopathological and molecular parameters
|
Variable |
n |
Means of survival time (years) / n |
p-value, Log Rank |
|
|---|---|---|---|---|
| GASC1 negative | GASC1 positive | |||
| Overall |
355 |
14.6/198 |
16.6/157 |
0.017 (0.012B, 0.013T-W) |
| Histological type |
|
|
|
|
| Ductal |
231 |
14.5/143 |
17.3/88 |
0.006 |
| Others |
124 |
14.8/ 55 |
15.4/69 |
0.608 |
| Tumor grade |
|
|
|
|
| I |
84 |
16.5/ 31 |
17.0/ 53 |
0.415 |
| II+III |
269 |
14.3/165 |
16.0/104 |
0.087 |
| unknown |
2 |
|
|
|
| ER status |
|
|
|
|
| negative |
77 |
13.4/ 51 |
15.2/ 26 |
0.322 |
| positive |
272 |
15.0/143 |
16.7/129 |
0.043 (0.027 B) |
| unknown |
6 |
|
|
|
| PR status |
|
|
|
|
| negative |
137 |
13.6/ 91 |
16.5/ 46 |
0.061 (0.042 B) |
| positive |
212 |
15.4/103 |
16.5/109 |
0.251 |
| unknown |
6 |
|
|
|
| HER2 status |
|
|
|
|
| negative |
290 |
15.3/156 |
17.4/134 |
0.018 (0.003 B) |
| positive |
45 |
12.1/ 32 |
13.0/ 13 |
0.704 |
| unknown |
20 |
|
|
|
| HER2-/ductal/grade II |
90 |
14.4/49 |
18.1/41 |
0.015 |
| Triple negative | 39 | 14.6/29 | 18.0/10 | 0.196 |
p- value for test of equality of survival distributions for the different levels of GASC1, B: Breslow (Generalized Wilcoxon),T-W: Tarone –Ware, n – number of cases.