Table 3.
Distribution of gene variants in children from the group of uncomplicated malaria and that of asymptomatic children
| Gene Variant | Unc malar (n=179) | Asym (n=138 ) | OR (95%CI) | P value | |
|---|---|---|---|---|---|
|
IL10RA ss491228441 T/G |
Genotypes |
|
|
|
|
| TT |
176 (0.98) |
125 (0.91) |
|
|
|
| TG |
3 (0.02) |
13 (0.09) |
|
|
|
| GG |
0 (0) |
0 (0) |
|
|
|
| Allele |
|
|
|
|
|
| T |
355 (0.99) |
263 (0.95) |
Reference |
||
| G |
3 (0.01) |
13 (0.05) |
0.16 (0.04-0.61) |
0.007 |
|
| Dominant |
|
|
|
|
|
| TT |
176 (0.98) |
125 (0.91) |
6.35 (1.68-23.9) |
0.006 |
|
| TG+GG |
3 (0.02) |
13 (0.09) |
|
|
|
| Recessive |
|
|
|
|
|
| GG |
0 (0) |
0 (0) |
NA |
||
| TT+TG |
179 (1.0) |
138 (1.0) |
|||
| STAT6 rs3024944 G/C | Genotypes |
|
|
|
|
| GG |
145 (0.81) |
106 (0.77) |
|
|
|
| GC |
30 (0.17) |
17 (0.12) |
|
|
|
| CC |
4 (0.02) |
15 (0.11) |
|
|
|
| Allele |
|
|
|
|
|
| G |
320 (0.89) |
229 (0.82) |
Reference |
||
| C |
38 (0.11) |
47 (0.18) |
0.57 (0.35-0.91) |
0.019 |
|
| Dominant |
|
|
|
|
|
| GG |
145 (0.81) |
106 (0.77) |
NS |
||
| GC+CC |
34 (0.19) |
32 (0.23) |
|||
| Recessive |
|
|
|
|
|
| CC |
4 (0.02) |
15 (0.11) |
0.17 (0.05-0.55) |
0.003 |
|
| GG+GC | 175 (0.98) | 123 (0.89) | |||
NA: not applicable; NS: not significant; Unc malar: uncomplicated malaria; Asym: asymptomatic, Odds ratio and P value were calculated by using binary logistic regression model and adjusted for age and gender.