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Therapeutic utility of IGF-I. A, IGF-I (100 nM) treatment for 24 hours stimulates frataxin in human astrocytes (n=3, independent experiments). B, One month of treatment of YG8R mice (4–6 months-old) with subcutaneous IGF-I (Alzet minipumps, 50 μg/kg/day) resulted in normalization of motor coordination in the rota-rod (F=10.1; n= 8–30). No effects on body weight were observed in treated mice. *p<0.05.
