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IGF-I acts through mTOR in frataxin-deficient cells and normal neurons. IGF-I stimulates frataxin in a rapamycin (100nM) sensitive way in frataxin-deficient astrocytes (A) and neurons (B). C, IGF-I increases phosphorylation of mTOR in neuronal cultures. Representative blot are shown; the upper blots correspond to frataxin and the lower blots to β-actin (n=3-4, independent experiments). *p<0.05; **p<0.01.
