Figure 1. Bleomycin-induced lung phenotype of Blmpf2 subcongenic mice.

The mice were treated with bleomycin by mini-osmotic pump and euthanized 42 days later. The percentage of the lung with fibrosis was determined from image analysis of histological sections and the mean ± SEM of 10–19 bleomycin-treated mice for each subcongenic line, and for the parental strains, is given. * indicates a significant difference in fibrosis from B6 mice, p<0.05. Genotypes [C3H alleles (white box); B6 alleles (black box)] were determined with microsatellite and SNP markers; genotypes of line 6 are expanded at the bottom of the figure.