Table 1. Summary of GWAS scan and replication studies for association between rs12296850 at 12q23.1 and risk of lung squamous cell carcinoma (SqCC).

Study	GG/AG/AA genotypes		G allele frequency		ORhet	ORhomo	ORadd	P add a
	Cases	Controls	Cases	Controls	(95% CI)a	(95% CI)a	(95% CI)a
GWAS	35/287/511	185/1204/1705	0.214	0.254	0.76(0.63–0.92)	0.50(0.32–0.77)	0.73(0.63–0.86)	9.30×10−5
Replication I	38/254/517	127/856/1241	0.204	0.250	0.69(0.57–0.85)	0.68(0.43–1.06)	0.75(0.63–0.88)	5.08×10−4
Replication II	86/447/832	289/1547/2235	0.227	0.261	0.77(0.67–0.88)	0.77(0.59–1.01)	0.82(0.74–0.91)	3.47×10−4
Combined All	159/988/1860	601/3607/5181	0.217	0.256	0.74(0.67–0.81)	0.68(0.56–0.83)	0.78(0.72–0.84)	1.19×10−10

^aAdjusted for age, gender, pack-year of smoking and the first principle component in GWAS, and for age, gender and pack-year of smoking in replication studies; OR_het: AG vs. AA; OR_homo: GG vs. AA; OR_add and P_add: derived from additive model.