Skip to main content
. 2013 Jan 17;9(1):e1002859. doi: 10.1371/journal.pcbi.1002859

Figure 6. DNL pathway in the big picture.

Figure 6

Circles represent the metabolites, and arrows represent reactions. Big rectangles represent compartments that reaction take place in (e.g., blood, cytosol, mitochondrion). DNL pathway holds an important place in the carbon flow of the liver cell. The glucose entering the cell can be utilized in the TCA cycle or can be converted to Triglycerides (TG) for storage. DNL pathway is particularly relevant to CF since it has been showed that mice with CF exhibit low lipogenesis and deposition of newly synthesize fatty acids into adipose tissue [47].