Table 1.
In vitro results of NHAC-kn cultured on HDM_derm and CTR for 7 and 14 days
| |
HDM_derm |
CTR |
Two-way ANOVA |
||
|---|---|---|---|---|---|
| 7 days | 14 days | 7 days | 14 days | ||
| CPII (pg/mg) |
79.0 ± 13.5* |
145.0 ± 21.2*,° |
39.8 ± 13.8 |
71.0 ± 7.4 |
F=6.9, p < 0.05 |
| Aggrecan (ng/mg) |
490.8 ± 60.0 |
937.4 ± 76.2***,°°° |
517.6 ± 32.8 |
583.4 ± 20.8 |
F=66.5, p < 0.0005 |
| TGF-β1 (pg/mg) |
2821.7 ± 145.7 |
2785.6 ± 405.1 |
3015.7 ± 125.6 |
2332.3 ± 89.4° |
F=10.2, p < 0.05 |
| IL-1β (pg/mg) |
0.8 ± 0.1 |
1.0 ± 0.2 |
0.8 ± 0.0 |
0.8 ± 0.0 |
NS |
| MMP3 (ng/mg) | 5.8 ± 3.8** | 3.3 ± 1.5 | 18.6 ± 1.7 | 5.8 ± 0.2°° | F=16.7, p < 0.005 |
Bonferroni t test (Mean ± SD, n = 8 replicates):
- between HDM_derm and CTR within each experimental time: *, p<0.05; **, p<0.005; ***, p<0.0005.
- between experimental times within each tested membrane: °, p<0.05; °°, p<0.005; °°°, p<0.0005.