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Clinical criteria for testing for CDH1 germline mutations [40]
| • |
1 diffuse gastric cancer case below age 40, or |
| • |
2 gastric cancer cases in a family, one confirmed diffuse gastric cancer below age 50, or |
| • |
3 confirmed diffuse gastric cancer cases in 1st or 2nd degree relatives independent of age, or |
| • | Personal or family history of diffuse gastric cancer and lobular breast cancer, with one diagnosis below age 50 |
